Ensure that your Mac has the latest version of macOS.Test your problem in Safe Mode and then exit Safe Mode and test your problem again. Restart your Mac: You can restart your Mac by going to the Apple menu > restart.Restart the app: First quit the app (Command, q or click Excel > Quit Excel, Quit Word, or Quit PowerPoint), and then try to open your file.In this article, we explain how you can troubleshoot the Office problems on your Mac. If you are having this problem, you will not be able to view, edit, or create Office files on your Mac. For example, when they want to open an Excel file, the file crashes, freezes, or won’t open at all. Several users have reported that they could not open their Microsoft Office (Excel, Word, PowerPoint, etc) files on the Mac. Facebook Twitter Pinterest LinkedIn Print Email